Figure 1. Decline in Logical Memory by joint APOE ε4 and Aβ status.

Estimates from linear mixed models predicting change in Logical Memory scores for groups based on joint APOE ε4/Aβ status. Decline in the high Aβ/APOE ε4+ group is greater than other groups for (A) Mini-Mental State Examination (MMSE), (B) Logical Memory immediate recall, and (C) delayed recall. Each plotted line extends to the longest follow-up period within that group. Aβ = β-amyloid.