Table 2. Pathway analyses: (A) biological pathways, (B) disease and disorders.

	Ingenuity pathways				KEGG pathways			GeneGO pathways
(A)	Numbers	Top canonical pathways	P-value	Ratio	Pathway name	Enrichment score	Enrichment P-value	Networks	P-value	Ratio
GRPS-11, top DBP KO genes out of CFG score ≥8.0 genes (n=11 genes)	1	GαI signaling	4.68E−05	3/135 (0.022)	Cocaine addiction	11.9589	6.40226E−06	Neurophysiological process_Transmission of nerve impulse	6.010E−06	6/212
	2	cAMP-mediated signaling	2.64E−04	3/226 (0.013)	Gap junction	5.71209	0.00330577	Development_Neurogenesis in general	9.163E−04	4/192
	3	G-protein-coupled receptor signaling	4.37E−04	3/276 (0.011)	Glutamatergic synapse	5.21128	0.00545466	Reproduction_GnRH signaling pathway	6.603E−03	3/166
	4	14-3-3-mediated signaling	2.14E−03	2/121 (0.017)	Dopaminergic synapse	5.0126	0.00665355	Transport_Synaptic vesicle exocytosis	7.762E−03	3/176
	5	Synaptic long-term depression	3.33E−03	2/161 (0.012)	Neuroactive ligand–receptor interaction	3.62169	0.0267375	Development_Neurogenesis_Synaptogenesis	8.258E−03	3/180

	Ingenuity				GeneGO
(B)	Number	Diseases and disorders	P-value	Molecules	Diseases	P-value	Ratio
GRPS-11, top DBP KO genes out of CFG score ≥8.0 genes (n=11 genes)	1	Hereditary disorder	1.66E−08 to 1.29E−02	9	Schizophrenia	1.476E−10	11/1033
	2	Neurological disease	1.66E−08 to 1.64E−02	10	Suicide	1.076E−09	6/151
	3	Psychological disorders	1.66E−08 to 1.53-02	9	Depressive disorder, major	2.106E−09	10/966
	4	Cancer	1.90E−08 to 1.82E−02	10	Bipolar disorder	2.983E−09	9/706
	5	Skeletal and muscular disorders	1.50E−07 to 1.34E−02	6	Alcoholism	3.468E−09	7/291

Abbreviations: CFG, Convergent Functional Genomics; DBP, D-box-binding protein. Pathway analyses of top candidate genes.