Table 2.
Univariate and multivariate analysis of IC-PFS, median survival and incidence of grade 2 leukoencephalopathy
| IC-PFS (m) Median | Univariate p -value | Multivariate p -value | MS(m) | Univariate p -value | Multivariate p -value | Leukoencephalopathy No. of patients (%) | Univariate p -value | Multivariate p -value | |
|---|---|---|---|---|---|---|---|---|---|
|
Gender |
|
|
|
|
|
|
|
|
|
| Male |
6 |
0.020 |
0.869 |
7 |
0.019 |
0.983 |
3/20 (15.5) |
0.024 |
0.562 |
| Female |
18 |
|
|
18 |
|
|
5/9 (55.6%) |
|
|
|
Age (years) |
|
|
|
|
|
|
|
|
|
| ≥60 |
8 |
0.628 |
|
8 |
0.719 |
|
5/18 (27.8) |
0.794 |
|
| <60 |
12 |
|
|
12 |
|
|
3/11 (27.3) |
|
|
|
KPS scores |
|
|
|
|
|
|
|
|
|
| ≥70 |
12 |
0.251 |
|
12 |
0.223 |
|
5/19 (26.3) |
0.833 |
|
| <70 |
3 |
|
|
4.4 |
|
|
3/10(30) |
|
|
|
Pathology |
|
|
|
|
|
|
|
|
|
| Adenocarcinoma |
14 |
0.015 |
0.519 |
14 |
0.011 |
0.553 |
6/13 (46.2) |
0.044 |
0.084 |
| Non-adenocarcinoma |
3 |
|
|
4.4 |
|
|
2/16 (12.5) |
|
|
|
RPA class |
|
|
|
|
|
|
|
|
|
| 2 |
12 |
0.266 |
|
12 |
0.185 |
|
5/19 (26.3) |
0.833 |
|
| 3 |
3 |
|
|
4.4 |
|
|
3/10 (30.0%) |
|
|
|
GPA scores |
|
|
|
|
|
|
|
|
|
| 0-1 |
6 |
0.331 |
|
7 |
0.188 |
|
4/13 (30.8) |
0.730 |
|
| 1.5-3.5 |
14 |
|
|
14 |
|
|
4/16 (25%) |
|
|
|
SIR scores |
|
|
|
|
|
|
|
|
|
| ≤5 |
3 |
0.001 |
0.044 |
4.4 |
<0.001 |
0.021 |
5/13 (38.5) |
0.238 |
|
| >5 |
14 |
|
|
14 |
|
|
3/16 (18.75) |
|
|
|
History of EGFR-TKI treatment |
|
|
|
|
|
|
|
|
|
| Yes |
16 |
0.026 |
0.035 |
18 |
0.022 |
0.040 |
7/11 (63.6) |
0.001 |
0.010 |
| No |
6 |
|
|
7 |
|
|
1/18 (5.6) |
|
|
|
Number of lesions |
|
|
|
|
|
|
|
|
|
| <3 |
14 |
0.005 |
0.036 |
14 |
0.007 |
0.048 |
6/15 (40.0) |
0.122 |
|
| ≥3 |
3 |
|
|
6 |
|
|
2/14 (14.3) |
|
|
|
Maximum lesion volume |
|
|
|
|
|
|
|
|
|
| <3 cc |
14 |
0.209 |
|
14 |
0.081 |
|
4/12 (33.3) |
0.561 |
|
| ≥3 cc |
4.4 |
|
|
6 |
|
|
4/17 (23.5) |
|
|
|
Total volume of lesions |
|
|
|
|
|
|
|
|
|
| <7 cc |
14 |
0.032 |
0.232 |
14 |
0.037 |
0.256 |
5/15 (33.3) |
0.474 |
|
| ≥7 cc |
3 |
|
|
6 |
|
|
3/14 (21.4) |
|
|
| Total | 10 | 10 | 8/29 (27.6) |
Abbreviations: IC-PFS = intracranial progression-free survival; MS = median survival; m = month; RPA = recursive partitioning analysis; GPA = graded prognostic assessment; SIR = score index for radiosurgery in brain metastases; EGFR-TKI = epidermal growth factor receptor- tyrosine kinase inhibitor.