Table 3.
Select human antimicrobial peptides and their proposed targets.
| APD ID | AMP | Structure | Molecular target |
|---|---|---|---|
| 181 | HD-6 | β | Aggregate on bacterial surface |
| 283 | hBD-3 | αβ | Bacterial cell wall (lipid II) |
| 176 | HNP-1 | β | Bacterial cell wall (lipid II) |
| 2257 | Lysozyme | α | Cell wall carbohydrate |
| 2071 | RegIIIα | αβ | Membrane pores |
| 310 | LL-37 | α | Bacterial membranes and/or DNA |
| 433 | Dermcidin | α | Membranes ion channel |
| 2017 | hGAPDH(2-32) | Unknown | Intracellular targets of fungi |
| 505 | Histatin 5 | α | Intracellular mitochondria |
| 2352 | Chromagranin A-derived peptides | Unknown | Cytoplasmic calmodulin of neutrophils |
| 1161 | Granulysin | α | Perforin generates a pore to allow granulysin to enter the cell and kill intracellular bacteria |