Table 2.
Incidence of response of VTT neurons to each pruritogen or partial pruritogen
| Drug | No. Responsive to Drug | Mechanical Classification |
Heat | ||
|---|---|---|---|---|---|
| HT | WDR | LT | |||
| 5-HT (47 mM) | 26 of 95 (27%) | 11 (42%) | 15 (58%) | 0 | 8 of 21 (38%) |
| BAM (1 mM) | 6 of 27 (22%) | 5 (83%) | 1 (17%) | 0 | 2 of 6 (33%) |
| CQ (100 mM) | 7 of 81 (9%) | 2 (29%) | 5 (71%) | 0 | 2 of 7 (29%) |
| HA (900 mM) | 26 of 92 (28%) | 13 (50%) | 13 (50%) | 0 | 9 of 25 (36%) |
| CAP (3.3 mM) | 13 of 49 (27%) | 6 (46%) | 7 (54%) | 0 | 5 of 12 (42%) |
| COW (≥10 spicules) | 0 of 49 | 0 | 0 | 0 | 0 |
For mechanical classification and heat responsiveness, percentages are calculated by dividing the number of neurons responding to noxious stimulus (denoted by column) by the number of neurons responding to the pruritogen or partial pruritogen (denoted by row).
HT, high threshold; WDR, wide dynamic range; LT, low threshold; 5-HT, serotonin; BAM, BAM8-22; CQ, chloroquine; HA, histamine; CAP, capsaicin; COW, cowhage.