Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
While all subjects exhibited some degree of negative effort dependence, there was substantial variability among subjects. Subject 1 (a control) demonstrates >50% negative effort dependence, and there is no clear plateau. In contrast, subject 4, who has obstructive sleep apnea (OSA), shows only ∼20% decrement from peak flow with increased effort, with a clear plateau in airflow. This plateau in flow could be due to anatomy or compensatory inspiratory phasic muscle activation.
