Table 1.
Characteristics of studies included in the meta-analysis of apolipoprotein E gene ε2/ε3/ε4 polymorphism and glaucoma*
| Author/Year [Reference] | Ethnicity | Sample size (Case/control) | Glaucoma type |
Number of cases |
Number of controls |
HWE P-value | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| ε2 | ε3 | ε4 | ε2 | ε3 | ε4 | |||||
| Krumbiegel 2010 [11] |
Caucasian (German) |
801(459/342) |
PEXG |
79 |
740 |
99 |
51 |
547 |
86 |
0.926 |
| Krumbiegel 2010 [11] |
Caucasian (Italian) |
323(133/190) |
PEXG |
21 |
222 |
23 |
23 |
317 |
40 |
0.024 |
| Saglar 2009 [12] |
Caucasian |
194(75/119) |
POAG |
13 |
126 |
11 |
10 |
204 |
24 |
0.832 |
| Al-Dabbagh 2009 [13] |
Asian |
230(100/130) |
POAG,PACG |
0 |
181 |
19 |
0 |
249 |
11 |
0.969 |
| Jia 2009 [14] |
Asian |
376(176/200) |
POAG |
34 |
278 |
40 |
35 |
329 |
36 |
0.897 |
| Yuan 2007 [15] |
Asian |
162(105/57) |
POAG,PACG |
48 |
81 |
81 |
18 |
76 |
20 |
<0.0001 |
| Zetterberg 2007 [16] |
Caucasian |
429(242/187) |
POAG |
50 |
376 |
58 |
42 |
289 |
43 |
0.923 |
| Hu 2007 [17] |
Asian |
219(142/77) |
POAG |
17 |
229 |
38 |
11 |
129 |
14 |
0.409 |
| Tamura 2006 [18] |
Asian |
105(28/77) |
POAG |
3 |
42 |
11 |
12 |
135 |
7 |
0.079 |
| Lam 2006 [19] |
Asian |
700(400/300) |
POAG |
79 |
674 |
47 |
50 |
495 |
55 |
0.065 |
| Mabuchi 2005 [20] |
Asian |
489(310/179) |
POAG |
16 |
567 |
37 |
18 |
302 |
38 |
0.104 |
| Jünemann 2004 [21] |
Caucasian |
128(96/32) |
POAG |
19 |
146 |
27 |
9 |
40 |
15 |
0.012 |
| Lake 2004 [22] |
Caucasian |
504(155/349) |
POAG |
28 |
229 |
53 |
56 |
534 |
108 |
0.316 |
| Ressiniotis 2004 [23] |
Caucasian |
212(137/75) |
POAG |
35 |
199 |
40 |
16 |
114 |
20 |
NA# |
| Vickers 2002 [24] | Caucasian | 193(142/51) | POAG | 27 | 206 | 51 | 15 | 75 | 12 | 0.202 |
*HWE: Hardy-Weinberg equilibrium; PEXG: pseudoexfoliation glaucoma; POAG: primary open angle glaucoma; PACG: primary angle closure glaucoma; NA: not available. #Only allele frequency was extracted from the study.