Table 9.
Histomorphometric parameters of the thoracic aortas
| Parameter | Control | Diabetes | Diabetes + telmisartan |
|---|---|---|---|
| Internal diameter of aorta (mm) |
1.65 ± 0.18 |
1.23 ± 0.19
¶
|
1.54 ± 0.22# |
| Width of media (μm) |
117.39 ± 16.30 |
82.62 ± 9.32
¶
|
87.68 ± 11.11
¶
|
| Elastic fibres in media (arbitrary units) |
2.84 ± 0.23 |
2.54 ± 0.34* |
2.65 ± 0.27 |
| Collagen fibres in media (arbitrary units) |
0.66 ± 0.19 |
1.43 ± 0.31
¶
|
1.30 ± 0.10
¶
|
| Elastin/collagen ratio in media (%) |
4.28 ± 0.57 |
1.79 ± 0.035
¶
|
2.07 ± 0.50* |
| Smooth muscle cell nuclei |
78.86 ± 15.01 |
94.10 ± 21.12 |
89.17 ± 24.90 |
| CML (arbitrary units) | 0.53 ± 0.08 | 2.28 ± 1.05 ¶ | 1.55 ± 0.80 ¶ |
Values are expressed as means ± SD. CML, Nϵ-(carboxymethyl) lysine.
*P <0.05 vs Control; ¶ P <0.001 vs Control; #P <0.05 vs Diabetes.