Table 1.
Clinicopathologic characteristics and methylation status of Caveolin 1 in human esophageal tissues
| |
Number of samples |
Age (year) mean |
NMV |
Methylation status (cutoff 0.2) |
||||
|---|---|---|---|---|---|---|---|---|
| Clinical characteristics | Mean | p | Frequency | UM | M | p | ||
|
Barrett’s segment |
|
|
|
|
|
|
|
|
| Short-segment ( <3 cm ) |
14 |
62.3 |
0.327 |
>0.05§ |
71.4% |
4 |
10 |
> 0.05‡ |
| Long-segment ( > = 3 cm ) |
16 |
62.8 |
0.439 |
|
81.3% |
3 |
13 |
|
|
Histology |
|
|
|
|
|
|
|
|
| Normal esophagus |
67 |
64.4 |
0.134 |
|
25.4% |
50 |
17 |
|
| Barrett’s metaplasia |
60 |
63.7 |
0.374 |
< 0.01*/§ |
81.7% |
11 |
49 |
* < 0.01† |
| Dysplasia in Barrett’s esophagus |
40 |
65.3 |
0.254 |
< 0.01*/§/ < 0.01$/§ |
60.0% |
16 |
24 |
* < 0.01†/ $ < 0.05† |
| Low-grade dysplasia |
19 |
65.3 |
0.269 |
< 0.01*/§/ < 0.05$/§ |
57.9% |
8 |
11 |
* < 0.01†/ $ < 0.05† |
| High-grade dysplasia |
21 |
65.2 |
0.240 |
< 0.01*/§/ < 0.01$/§ |
61.9% |
8 |
13 |
* < 0.01†/ $ > 0.05† |
| EAC |
67 |
65.1 |
0.294 |
< 0.01*/§/ < 0.01$/§ |
65.7% |
23 |
44 |
* < 0.01†/ $ < 0.05† |
| Well differentiation |
10 |
66.2 |
0.344 |
>0.05§§ |
80.0% |
2 |
8 |
> 0.05‡ |
| Moderate differentiation |
24 |
66.1 |
0.29 |
|
58.3% |
10 |
14 |
|
| Poor differentiation |
22 |
65.5 |
0.297 |
|
63.6% |
8 |
14 |
|
| Unknown |
11 |
61 |
0.252 |
|
72.7% |
3 |
8 |
|
| ESCC |
26 |
62.5 |
0.326 |
< 0.01*/§ |
80.8% |
5 |
21 |
* < 0.01‡ |
| Well differentiation |
3 |
61.7 |
0.307 |
>0.05§§ |
100.0% |
0 |
3 |
> 0.05‡ |
| Moderate differentiation |
11 |
62.7 |
0.381 |
|
90.9% |
1 |
10 |
|
| Poor differentiation |
5 |
64.2 |
0.256 |
|
80.0% |
1 |
4 |
|
| Unknown |
7 |
61.1 |
0.299 |
|
57.1% |
3 |
4 |
|
|
Stage of EAC patients |
|
|
|
|
|
|
|
|
| I |
7 |
63 |
0.358 |
>0.05§§ |
71.4% |
2 |
5 |
> 0.05‡ |
| II |
15 |
65.2 |
0.286 |
|
73.3% |
4 |
11 |
|
| III |
25 |
64.6 |
0.284 |
|
56.0% |
11 |
14 |
|
| IV |
7 |
66.3 |
0.242 |
|
28.6% |
5 |
2 |
|
|
Lymph node metastasis in EAC patients |
|
|
|
|
|
|
|
|
| Negative |
25 |
64.9 |
0.314 |
>0.05§ |
64.0% |
9 |
16 |
> 0.05† |
| Positive |
25 |
64.6 |
0.276 |
|
56.0% |
11 |
14 |
|
|
Smoking status of EAC patients |
|
|
|
|
|
|
|
|
| Never |
6 |
58.5 |
0.325 |
>0.05§§ |
83.3% |
1 |
5 |
> 0.05‡ |
| Former |
24 |
68.5 |
0.276 |
|
62.5% |
9 |
15 |
|
| Current |
13 |
60.8 |
0.303 |
|
53.8% |
6 |
7 |
|
|
Alcohol consumption of EAC patients |
|
|
|
|
|
|
|
|
| Never |
16 |
65.3 |
0.285 |
>0.05§§ |
68.8% |
5 |
11 |
> 0.05‡ |
| Former |
15 |
63 |
0.302 |
|
66.7% |
5 |
10 |
|
| Current | 10 | 65.7 | 0.315 | 60.0% | 4 | 6 | ||
EAC: esophageal adenocarcinoma; ESCC: esophageal squamous cell carcinoma; NMV: normalized methylation value; UM, unmethylated; M, methylated; §Student's t test; *comparisons made to normal esophagus; *comparisons made to Barrett’s metaplasia; §§Kruskal-Wallis test; †Chi-square for independence test; ‡Fisher's exact test.