Table 2.

Summary of responses from the profiling experiments depicted in Fig. 1

Cell class	Criteria for classification		Total cells	% of total cells	% responsive cells in each cell class
	Average response to 100 mM [K+]o ± SD	Responsiveness to pharmacological compounds			SP	ACh	ATP	NE	H	Br	Glu
Ventral respiratory column (P7-8 mouse)
Class A	0.8 ± 0.4	Responsive to glutamate only and response to 100 mM [K+]o ≥ 0.1	220	13	0	0	0	0	0	0	78
Class B	0.3 ± 0.2	Responsive to other receptor agonists and response to 100 mM [K+]o ≥ 0.1	574	33	8	91	68	65	74	35	76
Class C	0.0 ± 0.0	Response to 100 mM [K+]o < 0.1	965	55	1	6	8	4	5	6	6
Dorsal root ganglia (P8 mouse)
Class A/B	Responsive	Response to 100 mM [K+]o ≥ 0.1	787	32	0	7	76	1	6	27	3
Class C	0	Response to 100 mM [K+]o < 0.1	1,673	68	0	7	86	0	0	5	0

The average response to 100 mM [K⁺]_o ± SD is a relative measure of the change in [Ca²⁺]_i elicited by 100 mM [K⁺]_o (i.e., change in the 340/380-nm ratio shown in figures and described in SI Materials and Methods). Larger numbers indicate a greater response or greater relative change in [Ca²⁺]_i elicited by high [K⁺]_o. The VRC dataset was compiled from five independent experimental trials using cells prepared separately from four different mice. The DRG dataset was compiled from six independent experimental trials using cells prepared separately from two different mice. ACh, acetylcholine; Br, bradykinin; Glu, glutamate; H, histamine; NE, norepinephrine; SP, substance P.