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. Author manuscript; available in PMC: 2014 May 28.
Published in final edited form as: Int J Urol. 2012 Oct 23;20(1):4–12. doi: 10.1111/j.1442-2042.2012.03210.x

Fig. 1.

Fig. 1

Hypothetical model showing possible bi-directional interactions between non-neuronal cells (A-urothelium; B-spinal cord glial cells) and nerves. Both urothelial cells and glial cells can be targets for transmitters and mediators released from nerves. In turn, these non-neuronal cells can release a number of mediators that can alter the responsiveness (or excitability) of sensory nerves. This suggests that non-neuronal cells might have the ability to change the gain of the system, thereby altering sensory functions.