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Selective inhibition of the proteasome chymotrypsin-like and caspase-like activity by BU-32
| Cell line | Chymotrypsin-like | Caspase-like | Trypsin-like | |||
|---|---|---|---|---|---|---|
| IC50 (nM) | IC50 (nM) | IC50 (nM) | ||||
| BU-32 | Bortezomib | BU-32 | Bortezomib | BU-32 | Bortezomib | |
| RPMI822G | 4.2 ± 0.38 | 6.7 ± 0.48 | 13.5 ± 0.87 | 15.1 ± 0.92 | >18 | >18 |
| MM1S | 2.9 ± 0.18 | 4.5 ± 0.32 | 9.2 ± 0.32 | 12.1 ± 0.87 | >18 | >18 |
| MM1R | 7.5 ± 0.56 | 8.6 ± 0.19 | 9.0 ± 0.42 | 10.1 ± 0.67 | >18 | >18 |
| U266 | 6.1 ± 0.42 | 8.4 ± 0.12 | 13.4 ± 0.56 | 18.0 ± 0.78 | >18 | >18 |
