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. 2014 May 12;7:81–91. doi: 10.2147/TACG.S35598

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© 2014 Yang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Chromatin organization aberrations in prostate cancer.

Note: Chromatin organizations are altered in prostate cancer through DNA looping, histone PTMs, ncRNAs, and chromosomal translocations, which differentially regulate gene expression.

Abbreviations: DNMT, DNA methyltransferase; PTMs, posttranslational modifications; RNA, ribonucleic acid; ncRNA, noncoding RNA; PRC2, polycomb repressive complex 2; HDAC, histone deacetylase; SWI/SNF, switch/sucrose nonfermentable; MLL, mixed-lineage leukemia; AR, androgen receptor; LSD1, lysine-specific demethylase 1.