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. 2014 Mar 5;289(15):10607–10619. doi: 10.1074/jbc.M113.528760

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Inhibition of autophagy enhanced cucurbitacin I-induced apoptosis in GBM cells. A, a CCK-8 assay was performed to assess cell viability in GBM cells treated with different concentrations of cucurbitacin I in the presence or absence of CQ for 48 h. Data are mean ± S.D. *, p < 0.05 compared with the control group. B, apoptotic ratios were assessed by cell death detection ELISA^Plus assay in GBM cells treated with cucurbitacin I in the presence or absence of CQ for 48 h. Data are mean ± S.D. **, p < 0.01. C, apoptotic ratios were assessed by TUNEL assay in GBM cells. Data are mean ± S.D. *, p < 0.05. GBM cells transiently transfected with control siRNA and Beclin 1 siRNA were treated with cucurbitacin I (100 nm) for 48 h. D, a CCK-8 assay was performed to assess cell viability. E, apoptosis was assessed by cell death detection ELISA^Plus assay. Data are mean ± S.D. *, p < 0.05.