TABLE 3.
Plasma data of 2-month-old mice
Data are the means ± S.D. n = 19–33 animals per genotype. Pi, inorganic phosphate; ALAT, alanine aminotransferase (EC 2.6.1.2); ASAT, aspartate aminotransferase (EC 2.6.1.1). Student's t test with Holm-Bonferroni correction: b, c, p < 0.05; bb, cc, p < 0.01; bbb, ccc, p < 0.001; b, homozygous mutant versus wild type; c, homozygous UmodC93F mutant versus homozygous UmodA227T mutant.
| Plasma parameters | Wild-type | UmodA227T homozygote | UmodC93F homozygote |
|---|---|---|---|
| Na+ (mmol/liter) | 148.5 ± 3.8 | 148.5 ± 3.0 | 148.5 ± 4.5 |
| K+ (mmol/liter) | 3.93 ± 0.34 | 4.21 ± 0.29bb | 4.00 ± 0.33 |
| Ca2+ (mmol/liter) | 2.34 ± 0.07 | 2.34 ± 0.07 | 2.36 ± 0.11 |
| Cl− (mmol/liter) | 109.8 ± 2.2 | 110.2 ± 1.9 | 110.8 ± 3.7 |
| Pi (mmol/liter) | 2.58 ± 0.36 | 2.57 ± 0.36 | 2.33 ± 0.29b |
| Total protein (g/liter) | 49.8 ± 2.6 | 48.3 ± 1.9b | 49.1 ± 2.3 |
| Creatinine (μmol/liter) | 8.57 ± 1.59 | 9.46 ± 1.61 | 8.64 ± 1.53 |
| Urea (mmol/liter) | 9.67 ± 1.17 | 14.0 ± 1.9bbb | 16.1 ± 2.6bbb,cc |
| Cholesterol (mmol/liter) | 3.40 ± 0.28 | 3.25 ± 0.24 | 3.21 ± 0.20b |
| Triglycerides (mmol/liter) | 1.31 ± 0.53 | 1.24 ± 0.48 | 1.07 ± 0.33 |
| ALAT (units/liter) | 28.2 ± 10.0 | 30.4 ± 16.1 | 34.4 ± 10.0b |
| ASAT (units/liter) | 41.2 ± 4.9 | 41.8 ± 5.1 | 46.3 ± 6.0bb,c |
| Lipase (units/liter) | 52.8 ± 10.2 | 51.9 ± 11.0 | 54.3 ± 8.6 |