FIGURE 6.

Dasatinib inhibits radiation-induced apoptosis in vivo. A, mice were irradiated to the head and neck with 25 Gy of γ-irradiation with or without the application of dasatinib (20 mg/kg) by oral gavage 1 h before and 3 h after IR. Salivary glands were removed, sectioned, and stained for activated caspase-3 as described under “Experimental Procedures.” Shown is a representative image for each condition (magnification, ×60). B, positively stained cells were quantified and expressed as the percentage of caspase-3-positive/total cells; >3000 cells were counted per condition. Data shown represent the average value plus the S.E. (error bars) (n = 7); * indicates a significant difference compared with mice treated with IR only (p < 0.05, t test).