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M2 Inhibitors with an Appended Aromatic Groupa
| Structure |
|
|
|
|---|---|---|---|
| 3 | 4 | 5-49 | |
| Rimantadine-based | Pinanamine-based | Amantadine-based (this work) | |
| S31N % inhibition (TEVC) | 0% | 0% | See the text |
| WT % inhibition (TEVC) | 27 ± 2% | 91 ± 2% |
The activity of the inhibitors was measured using the TEVC technique with full length AM2 protein in the Xenopus oocytes membrane; average of three measurements was reported (see Experimental Section in the Supporting Information).
