Table 4.
R1= | -H Amt | ||||||||
/ ID # | 1 | 5 | 20 | 29 | 30 | 31 | 32 | 33 | 34 |
S31N | |||||||||
% inh/ | 35 ± 2/ | 1 ± 1 | 42 ± 2/ | 18 ± 2 | 14 ± 1 | 6 ± 2 | 1 ± 1 | 0% | 6 ± 2 |
IC50 | 199.9 μM | 166 μM | |||||||
WT | |||||||||
% inh/ | 91 ± 3/ | 77 ± 1 | 67 ± 2 | 81 ± 2 | 22 ± 2 | 66 ± 3 | 48 ± 1 | 12 ± 1 | 88 ± 1 |
IC50 | 16.1 μM |