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. Author manuscript; available in PMC: 2014 May 28.
Published in final edited form as: J Med Chem. 2013 Mar 27;56(7):2804–2812. doi: 10.1021/jm301538e

Table 4.

SAR of 2- and 3-Substituted Adamantan-1-yl-benzyl-amines

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/ ID # 1 5 20 29 30 31 32 33 34
S31N
% inh/ 35 ± 2/ 1 ± 1 42 ± 2/ 18 ± 2 14 ± 1 6 ± 2 1 ± 1 0% 6 ± 2
IC50 199.9 μM 166 μM
WT
% inh/ 91 ± 3/ 77 ± 1 67 ± 2 81 ± 2 22 ± 2 66 ± 3 48 ± 1 12 ± 1 88 ± 1
IC50 16.1 μM