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. 2014 Mar 4;289(16):10975–10987. doi: 10.1074/jbc.M113.542654

FIGURE 1.

FIGURE 1.

XAP044 selectively antagonizes [35S]GTPγS binding via mGlu7. A, concentration-response curves for XAP044 (XAP) and LY341495 (LY) against agonist (EC90)-stimulated [35S]GTPγS (GTPγ[35S]) binding on membranes from CHO cells stably expressing either GABAB, mGlu4, mGlu6, or mGlu7b. B, concentration-response curves for XAP044 using [35S]GTPγS binding on membranes from CHO cells stably expressing mGlu7a or mGlu7b activated with AMN082 (AMN; 3 μm) or DL-AP4 (4 mm). All data points represent the mean ± S.E. from at least three independent measurements (n ≥ 3) normalized to the control stimulation of near-maximal agonist concentrations (e.g. 4 mm DL-AP4 in the case of mGlu7, set to 100%). C, chemical structures of XAP044, LY341495, DL-AP4, AMN082, MMPIP, and ADX71743.