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. 2014 Feb 28;289(16):11059–11067. doi: 10.1074/jbc.M114.552281

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Forcible targeting of Rab27A(Q78L) to mature melanosomes in melanocytes by the MST tag. A, typical images of melanocytes expressing mStr-tagged Rab27A(Q78L) and MST-Rab27A(Q78L) (mStr fluorescence images and their corresponding bright-field images). Cells exhibiting perinuclear melanosome aggregation are outlined with a dashed line. The melanosomes in the merged images (right column) are pseudocolored green. The insets show magnified views of the boxed areas. In contrast to Rab27A(Q78L), MST-Rab27A(Q78L) was clearly targeted to mature melanosomes without inducing perinuclear melanosome aggregation (bottom row). Scale bars = 20 μm. B, the number of melanocytes exhibiting perinuclear melanosome aggregation expressed as a percentage of the number of transfected melanocytes shown in A. **, p < 0.01, unpaired Student's t test.