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Mutation of the putative catalytic arginines reduces GAP activity of ELMOD1–3 against ARL2. ELMOD (1 μm) wild type and arginine to lysine point mutants were tested for activity as GAPs for ARL2 using the standard GAP assay in duplicate, as described under “Experimental Procedures.” This experiment was repeated three times, and the results averaged as the amount of GTP hydrolyzed. The error bars represent mean ± S.E. values.
