Ectopic expression of SRC-3 enhanced bladder cancer cell aerobic glycolysis.
A, glucose consumption and lactate production in SRC-3 overexpressed and control cells under normoxia and hypoxia conditions. The mRNA and protein expression levels of glycolytic genes in the SRC-3 overexpressed and control cells were detected by quantitative RT-PCR assay (B) and Western blot assay (C). CTRL, BIU87 cells transfected with empty vector; #1 and #2, two stable transfectants of SRC-3. *, p < 0.05; **, p < 0.001.