FIGURE 4.

Knockdown of SRC-3 abrogated tumorigenicity of T24 bladder cancer cell in nude mice. A, in vivo tumor growth curve of SRC-3 knockdown and control xenografts over 7 weeks. Tumor size was measured by caliper and tumor volume was calculated by the formula: volume = (L × W²)/2. B, the average tumor weight of the SRC-3 knockdown (shSRC-3, n = 8) and control (shCTRL, n = 6) xenografts at the end point. C, Western blotting assay of SRC-3, PCNA, and LDHA protein expression levels in SRC-3 knockdown and control xenografts. Data, mean ± S.D. *, p < 0.05; **, p < 0.01; ***, p < 0.001.