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. 2014 Feb 28;289(16):11219–11229. doi: 10.1074/jbc.M113.535989

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Knockdown of glycolytic genes or HIF1α reduced SRC-3 overexpression accelerated bladder cancer cell proliferation. A, efficiency of RNA interference targeting HK-2 (siHK-2) and LDHA (siLDHA) in SRC-3 overexpressed (#1) and control cells determined by Western blot analysis. B–E, cell proliferation in SRC-3 overexpressed and control cells with the treatment of siHK-2 (B), siLDHA (C), 2-DG (12.5 mg/ml) (D), and sodium oxamate (80 mm) (E). F, efficiency of RNA interference-targeting HIF1α (siHIF1α) in SRC-3 overexpressed (#1) and control cells determined by Western blot analysis. G, cell proliferation in SRC-3 overexpressed (#1) and control (CTRL) cells with treatment of siHIF1α were detected by MTT assay. *, p < 0.05; **, p < 0.01; ***, p < 0.001.