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Schematic model for the epigenetic regulation of GnT-IX. In non-GnT-IX-expressing cells, chromatin around the GnT-IX gene is repressed by chromatin modifiers, including HDAC11. When GnT-IX chromatin is activated, TET3 recruits OGT. This OGT-TET3 complex further facilitates the recruitment of NeuroD1 to GnT-IX promoter, which in turn activates GnT-IX transcription. Pol-II, RNA polymerase II.
