Table 1.
Proportion of significant SNPs for genes in the mammary development pathway and number of SNPs significantly (P < 0.05) associated with each trait
Gene | Chr | Start | Stop | Nb SNPs | Fat | Fat % | Milk | Protein | Prot % |
---|---|---|---|---|---|---|---|---|---|
ADAM17 |
11 |
87798074 |
88040943 |
84 |
0.51 |
0.10 |
0.06 |
0.48 |
0.14 |
AREGB |
6 |
91026256 |
91238391 |
53 |
0.42 |
0.60 |
0.55 |
0.62 |
0.64 |
BMP4 |
10 |
66651296 |
66855026 |
51 |
0.10 |
0.45 |
0.22 |
0.20 |
0.24 |
BMPR1A |
28 |
41717915 |
41975988 |
55 |
0.00 |
0.02 |
0.20 |
0.31 |
0.04 |
CSN2 |
6 |
87079502 |
87288025 |
58 |
0.40 |
0.59 |
0.83 |
0.78 |
0.90 |
CCND1 |
29 |
47444380 |
47653820 |
43 |
0.35 |
0.35 |
0.16 |
0.12 |
0.44 |
DKK1 |
26 |
6752970 |
6955647 |
48 |
0.50 |
0.13 |
0.58 |
0.58 |
0.25 |
EDAR |
11 |
44351547 |
44567795 |
31 |
0.26 |
0.13 |
0.23 |
0.39 |
0.23 |
EGF |
6 |
16465618 |
16768065 |
103 |
0.08 |
0.09 |
0.12 |
0.12 |
0.00 |
EGFR |
22 |
792005 |
1169280 |
81 |
0.23 |
0.05 |
0.11 |
0.16 |
0.05 |
ESR1 |
9 |
89869586 |
90355801 |
103 |
0.21 |
0.19 |
0.33 |
0.38 |
0.13 |
FGF1 |
7 |
55408007 |
55701836 |
65 |
0.60 |
0.15 |
0.11 |
0.58 |
0.80 |
FGF10 |
20 |
30510292 |
30719199 |
30 |
0.03 |
0.50 |
0.50 |
0.00 |
0.63 |
FGFR1 |
27 |
33150508 |
33400219 |
43 |
0.14 |
0.21 |
0.19 |
0.47 |
0.19 |
GH1 |
19 |
48668618 |
48872014 |
73 |
0.08 |
0.16 |
0.32 |
0.26 |
0.34 |
GHR |
20 |
31790736 |
32299996 |
97 |
0.62 |
0.93 |
0.84 |
0.54 |
0.96 |
GLI2 |
2 |
72877209 |
73268370 |
82 |
0.16 |
0.10 |
0.11 |
0.27 |
0.05 |
GLI3 |
4 |
79344243 |
79858476 |
71 |
0.23 |
0.20 |
0.38 |
0.32 |
0.25 |
IGF1 |
5 |
66432877 |
66704734 |
49 |
0.37 |
0.24 |
0.31 |
0.24 |
0.18 |
IGF1R |
21 |
8108822 |
8368093 |
61 |
0.07 |
0.05 |
0.11 |
0.10 |
0.07 |
IRS1 |
2 |
115690540 |
115894253 |
22 |
0.18 |
0.32 |
0.14 |
0.41 |
0.09 |
IRS2 |
12 |
88564525 |
88769181 |
64 |
0.28 |
0.02 |
0.55 |
0.28 |
0.64 |
LEF1 |
6 |
18235031 |
18550774 |
59 |
0.25 |
0.08 |
0.20 |
0.31 |
0.00 |
MFGE8 |
21 |
20789913 |
21004968 |
52 |
0.21 |
0.42 |
0.37 |
0.33 |
0.29 |
MMP14 |
10 |
21706054 |
21914533 |
43 |
0.19 |
0.02 |
0.12 |
0.19 |
0.00 |
MMP2 |
18 |
23728638 |
23955657 |
94 |
0.12 |
0.11 |
0.12 |
0.10 |
0.55 |
MMP3 |
15 |
5928011 |
6134595 |
52 |
0.06 |
0.23 |
0.15 |
0.13 |
0.02 |
MMP9 |
13 |
75366513 |
75573824 |
45 |
0.33 |
0.04 |
0.56 |
0.53 |
0.04 |
MSX1 |
6 |
105961463 |
106165759 |
56 |
0.43 |
0.61 |
0.46 |
0.38 |
0.50 |
MSX2 |
20 |
6260600 |
6465489 |
39 |
0.05 |
0.49 |
0.41 |
0.18 |
0.54 |
NRG1 |
27 |
27523938 |
27933470 |
79 |
0.18 |
0.24 |
0.29 |
0.30 |
0.15 |
NRG3 |
28 |
38201492 |
38451092 |
66 |
0.02 |
0.02 |
0.00 |
0.02 |
0.00 |
NTN1 |
19 |
28984419 |
29369338 |
87 |
0.36 |
0.23 |
0.37 |
0.34 |
0.31 |
PGR |
15 |
8004485 |
8322755 |
64 |
0.48 |
0.13 |
0.38 |
0.48 |
0.06 |
PCBD1/TCF1 |
28 |
27126795 |
27331724 |
67 |
0.34 |
0.30 |
0.13 |
0.16 |
0.19 |
PRL |
23 |
35005135 |
35213759 |
53 |
0.19 |
0.04 |
0.11 |
0.19 |
0.36 |
PRLR |
20 |
38973246 |
39237480 |
56 |
0.48 |
0.61 |
0.50 |
0.25 |
0.82 |
PTHLH |
5 |
82146522 |
82358858 |
30 |
0.30 |
0.50 |
0.47 |
0.33 |
0.33 |
PTH1R |
22 |
53061302 |
53324114 |
48 |
0.40 |
0.15 |
0.13 |
0.35 |
0.23 |
PTH |
15 |
39628332 |
39830868 |
31 |
0.23 |
0.06 |
0.58 |
0.19 |
0.26 |
TNFRSF11A |
24 |
61139109 |
61375194 |
65 |
0.15 |
0.08 |
0.03 |
0.02 |
0.18 |
TNFSF11 |
12 |
12641069 |
12882474 |
73 |
0.33 |
0.56 |
0.05 |
0.08 |
0.51 |
RELN |
4 |
44792394 |
45389293 |
131 |
0.60 |
0.07 |
0.69 |
0.34 |
0.47 |
SIRPA |
13 |
53567570 |
53810792 |
80 |
0.70 |
0.09 |
0.46 |
0.73 |
0.48 |
SLIT2 |
6 |
41136589 |
41740789 |
145 |
0.09 |
0.18 |
0.17 |
0.19 |
0.46 |
SOCS1 |
25 |
9875299 |
10075970 |
56 |
0.30 |
0.00 |
0.16 |
0.32 |
0.00 |
SOCS2 |
5 |
23423981 |
23628860 |
46 |
0.28 |
0.67 |
0.59 |
0.52 |
0.67 |
SOCS3 |
19 |
54358856 |
54559555 |
62 |
0.44 |
0.21 |
0.18 |
0.40 |
0.50 |
STAT5A |
19 |
42933597 |
43154075 |
59 |
0.36 |
0.85 |
0.61 |
0.75 |
0.80 |
STAT5B |
19 |
42860226 |
43096671 |
60 |
0.10 |
0.83 |
0.78 |
0.55 |
0.80 |
TBX2 |
19 |
11843185 |
12051411 |
81 |
0.11 |
0.15 |
0.14 |
0.17 |
0.41 |
TBX3 |
17 |
62252245 |
62463636 |
45 |
0.27 |
0.20 |
0.33 |
0.18 |
0.29 |
TCF3 |
7 |
45499593 |
45730734 |
34 |
0.44 |
0.00 |
0.41 |
0.50 |
0.21 |
TCF4 |
24 |
54956409 |
55261459 |
73 |
0.03 |
0.14 |
0.19 |
0.23 |
0.05 |
TGFA |
11 |
13772149 |
14086616 |
65 |
0.42 |
0.26 |
0.40 |
0.55 |
0.11 |
TGFB1 |
18 |
50671354 |
50885924 |
55 |
0.42 |
0.58 |
0.49 |
0.71 |
0.65 |
TGFBR1 |
8 |
64470093 |
64741796 |
64 |
0.23 |
0.33 |
0.33 |
0.27 |
0.41 |
TGFBR2 |
22 |
5041232 |
5333083 |
92 |
0.14 |
0.13 |
0.15 |
0.12 |
0.07 |
WAP |
4 |
77111371 |
77312672 |
35 |
0.26 |
0.20 |
0.17 |
0.23 |
0.31 |
WNT10B |
5 |
30913104 |
31114446 |
44 |
0.14 |
0.91 |
0.91 |
0.09 |
0.86 |
WNT11 |
15 |
56284700 |
56504335 |
51 |
0.37 |
0.35 |
0.22 |
0.31 |
0.12 |
WNT3 |
19 |
45921803 |
46171153 |
55 |
0.11 |
0.36 |
0.13 |
0.11 |
0.78 |
WNT5A |
22 |
45996228 |
46212683 |
45 |
0.02 |
0.02 |
0.09 |
0.18 |
0.33 |
WNT6 |
2 |
107444683 |
107656681 |
64 |
0.34 |
0.52 |
0.56 |
0.44 |
0.34 |
N = 64 | 3968 | 1079 | 1034 | 1247 | 1249 | 1350 |
Bold values indicate where >50% of SNPs in a gene region were significant.