Table 3.
Proportion of significant SNPs for genes in the involution pathway and number of SNPs significantly (P < 0.05) associated with each trait
| Gene | Chr | Start | Stop | Nb SNP | Fat | Fat % | Milk | Protein | Prot % |
|---|---|---|---|---|---|---|---|---|---|
|
AKT1 |
21 |
70778138 |
70995537 |
30 |
0.17 |
0.17 |
0.13 |
0.13 |
0.17 |
|
ATF4 |
5 |
111362845 |
111564936 |
52 |
0.54 |
0.12 |
0.52 |
0.23 |
0.60 |
|
BAK1 |
23 |
7555892 |
7758885 |
31 |
0.19 |
0.16 |
0.23 |
0.03 |
0.45 |
|
BAX |
18 |
55885202 |
56089378 |
35 |
0.11 |
0.49 |
0.51 |
0.40 |
0.49 |
|
BCL2L1 |
13 |
61666806 |
61917383 |
28 |
0.04 |
0.07 |
0.50 |
0.36 |
0.11 |
|
CASP3 |
27 |
13984622 |
14210610 |
49 |
0.12 |
0.10 |
0.16 |
0.18 |
0.08 |
|
CEBPA |
18 |
43828610 |
44029840 |
30 |
0.10 |
0.13 |
0.20 |
0.07 |
0.13 |
|
CEBPD |
14 |
20638814 |
20840407 |
28 |
0.46 |
0.25 |
0.46 |
0.43 |
0.32 |
|
CEBPG |
18 |
43905707 |
44112657 |
68 |
0.24 |
0.06 |
0.15 |
0.16 |
0.03 |
|
CISH |
22 |
50220205 |
50425617 |
38 |
0.21 |
0.00 |
0.21 |
0.24 |
0.32 |
|
CTNNA1 |
7 |
51588098 |
51980519 |
14 |
0.14 |
0.79 |
0.14 |
0.21 |
0.00 |
|
CTNNA2 |
11 |
54622279 |
56182035 |
514 |
0.23 |
0.40 |
0.53 |
0.48 |
0.38 |
|
E2F1 |
13 |
63605710 |
63814008 |
21 |
0.62 |
0.10 |
0.48 |
0.43 |
0.19 |
|
FOXO3 |
9 |
41908606 |
42218673 |
56 |
0.09 |
0.02 |
0.09 |
0.14 |
0.00 |
|
IGFBP5 |
2 |
105278991 |
105497646 |
61 |
0.62 |
0.08 |
0.21 |
0.64 |
0.72 |
|
IL11 |
18 |
62461915 |
62664977 |
61 |
0.51 |
0.11 |
0.05 |
0.36 |
0.16 |
|
IL6 |
4 |
31478311 |
31682667 |
25 |
0.40 |
0.00 |
0.24 |
0.36 |
0.00 |
|
IL6ST |
20 |
23112633 |
23370316 |
64 |
0.23 |
0.39 |
0.28 |
0.39 |
0.67 |
|
IRF1 |
7 |
23135653 |
23343697 |
46 |
0.72 |
0.00 |
0.61 |
0.67 |
0.20 |
|
JAK1 |
3 |
80675557 |
81015026 |
65 |
0.18 |
0.45 |
0.55 |
0.35 |
0.46 |
|
JAK2 |
8 |
39531342 |
39850796 |
32 |
0.28 |
0.47 |
0.63 |
0.56 |
0.44 |
|
LEF1 |
6 |
18235031 |
18550774 |
59 |
0.25 |
0.08 |
0.20 |
0.31 |
0.00 |
|
LIF |
17 |
71313855 |
71518166 |
53 |
0.13 |
0.02 |
0.09 |
0.26 |
0.08 |
|
LIFR |
20 |
35817479 |
36066671 |
74 |
0.54 |
0.58 |
0.68 |
0.58 |
0.80 |
|
MMP2 |
18 |
23728638 |
23955657 |
94 |
0.12 |
0.11 |
0.12 |
0.10 |
0.55 |
|
MMP3 |
15 |
5928011 |
6134595 |
52 |
0.06 |
0.23 |
0.15 |
0.13 |
0.02 |
|
MMP9 |
13 |
75366513 |
75573824 |
45 |
0.33 |
0.04 |
0.56 |
0.53 |
0.04 |
|
MYC |
14 |
13669244 |
13874438 |
38 |
0.61 |
0.76 |
0.24 |
0.13 |
0.32 |
|
OSM |
17 |
71334468 |
71537372 |
51 |
0.16 |
0.06 |
0.06 |
0.24 |
0.08 |
|
OSMR |
20 |
35421410 |
35688186 |
53 |
0.60 |
0.70 |
0.64 |
0.58 |
0.74 |
|
TP53 |
19 |
27885495 |
28097841 |
23 |
0.43 |
0.48 |
0.22 |
0.43 |
0.17 |
|
PTEN |
26 |
9398226 |
9695849 |
33 |
0.03 |
0.36 |
0.42 |
0.36 |
0.42 |
|
PTK2 |
14 |
3770893 |
4165010 |
121 |
0.79 |
0.90 |
0.84 |
0.66 |
0.82 |
|
RAF1 |
22 |
57022412 |
57304951 |
115 |
0.34 |
0.06 |
0.47 |
0.52 |
0.01 |
|
SFRP4 |
4 |
49909882 |
50120466 |
51 |
0.22 |
0.49 |
0.59 |
0.57 |
0.47 |
|
SOCS3 |
19 |
54358856 |
54559555 |
62 |
0.44 |
0.21 |
0.18 |
0.40 |
0.50 |
|
STAT3 |
19 |
42956660 |
43232624 |
58 |
0.43 |
0.84 |
0.53 |
0.78 |
0.84 |
|
STAT5A |
19 |
42933597 |
43154075 |
59 |
0.36 |
0.85 |
0.61 |
0.75 |
0.80 |
|
STAT5B |
19 |
42860226 |
43096671 |
60 |
0.10 |
0.83 |
0.78 |
0.55 |
0.80 |
|
TIMP3 |
5 |
71651415 |
71909052 |
72 |
0.54 |
0.21 |
0.49 |
0.38 |
0.42 |
| N = 40 | 2521 | 803 | 841 | 1048 | 1044 | 972 |
Bold values indicate where >50% of SNPs in a gene region were significant.