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. 2014 Mar 20;289(19):13295–13307. doi: 10.1074/jbc.M114.550541

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Thrombin-induced up-regulation of MMP-1 (A) and COX2 (B) is not mediated by PAR-1. Aa and Ba, effect of a PAR-1-selective receptor antagonist (SCH79797, 2 μm) and thrombin (2 units/ml, 18 nm) on MMP1 (Aa) and COX2 (Ba) mRNA levels in amnion mesenchymal cells. Cells were pretreated with SCH79797 30 min prior to thrombin treatment. Data represent mean ± S.D. (error bars), n = 3 in each group. *, p < 0.05; **, p < 0.01; N.S., not significant. A.U., arbitrary units. Ab and Bb, effect of control (open bars) or PAR-1 AP (TFLLRN, 200 μm, filled bars) on MMP1 (Ab) and COX2 (Bb) mRNA in amnion mesenchymal cells treated for 24 or 48 h. Data represent mean ± S.D. (error bars), n = 3 in each group. *, p < 0.05; **, p < 0.01; N.S., not significant. Ac and Bc, effect of control (open bars), thrombin (2 units/ml, 18 nm, gray bars), hirudin (4 units/ml, white bars), or thrombin + hirudin (filled bars) on MMP1 (Ac) and COX2 (Bc) mRNA in amnion mesenchymal cells treated for 48 h. Data represent mean ± S.D., n = 3 in each group. **, p < 0.01.