Intrathecal treatment with l-Stable Chem reduces CCI-induced neuropathic pain. Intrathecal injection of l-Stable Chem (100 pmol), 1 week after CCI, reduces CCI-induced mechanical hypersensitivity (A and C), and cold allodynia (E). Intrathecal injection of ResolvinE1 (RvE1) (100 pmol), 1 week after CCI, reduces CCI-induced mechanical hypersensitivity (B and D) and cold allodynia (F). BL, baseline before surgery. Data are representative of the mean ± S.E. from n = 5–8 mice per group. Comparison of control to l-Stable Chem or Resolvin-E1 is shown: *, p < 0.05.