Skip to main content
. 2014 Mar 18;289(19):13492–13502. doi: 10.1074/jbc.M114.549832

FIGURE 5.

FIGURE 5.

HSA K573P shows extended serum half-life in mice and cynomolgus monkeys. A and B, log-linear changes in serum concentrations of WT HSA, K500A, and K573P in WT NMRI mice (A, 18 mice/group, 6 mice/time point) and FcRn−/− hFcRn Tg32 mice (B, 10 mice/group, 5 mice/time point). HSA variants were administered by intravenous infusions at 10 mg/kg, followed by collecting serum samples from the tail vein before the serum HSA concentrations were determined using an AlphaLISA immunoassay. C, log-linear changes in serum concentrations of WT HSA and K573P in cynomolgus monkeys (2 monkeys/group). HSA variants were administered by intravenous infusions at 1 mg/kg, followed by collecting serum samples before the HSA concentrations were determined using an anti-c-Myc ELISA. The results are means ± standard errors.