FIGURE 3.

MBP enhances survival of cerebellar neurons exposed to oxidative or excitotoxic stress in an L1- and Le^x-dependent manner. WT (A and B) and L1-deficient (L1-/y) (A) cerebellar neurons were treated with H₂O₂ or glutamate (glu) in the absence or presence of MBP (A and B) and Le^x, Le^a, Le^x peptide (pep), or scrambled Le^x peptide (scr) (B). Mean values ± S.E. (*, p < 0.05; **, p < 0.01; ***, p < 0.001; two-tailed Student's t test) from four independent experiments with triplicates are shown for the numbers of viable cells relative to those determined without additives (set to 100%).