Figure 3.

Comparison of the ZNF repeat regions encoded by members of the (A) HSA19q13.2 and (B) Mmu7 ZNF gene families, showing the variation in number of finger motifs between genes, including closely related sets. Black boxes indicate typical C2H2-type ZNF repeats, and striped boxes denote clearly degenerate repeats, defined as any that lack one or more of the key cysteine or histidine residues, or has a variation in spacing between critical amino acid positions that might affect finger structure. Several of these genes have additional possible degenerate repeats in the `spacer' part of the spacer+fingers exon (the spacer would be at the 5′ end of the region illustrated); these range from obvious former fingers to barely recognizable potential remnants (only the degenerate fingers shown here were included in the alignments). LOC147711 has a 1-bp deletion that frameshifts the translation of the 3′ fingers which would otherwise be comparable to those of ZNF285.