Table 1.

Comparison of Distributions of Predicted Interactions in Functional Categories for Large-Scale Studies

	MTAa	TAPb	HMSc	Y2Hd	RNAe	SILf	SYNg
TAP	0.170
HMS	0.461	0.346
Y2H	0.436	0.518	0.325
RNA	0.701	0.087	0.384	0.060
SIL	0.556	0.350	0.474	0.023	0.740
SYN	0.578	0.332	0.107	0.677	0.016	0.005
HCh	0.739	0.488	0.542	0.318	0.869	0.799	0.248

^aOur Multimeric Threading Algorithm.

^bTAP complexes.

^cHMS-PCI complexes.

^dYeast two-hybrid.

^eCorrelated mRNA expression.

^fOther in silico methods.

^gSynthetic lethality.

^hHigh confidence interactions, i.e., the interactions determined by at least two different large-scale methods.