Table 2.

Univariate and multivariate analysis of prognostic factors for overall survival and distant failure

Variable	Median	Univariate	Multivariate analysis
	Survival time (months)	Analysis P value	Hazard ratio (95% CI)	P value
Overall survival
Sex, male vs female	male (16.1); female (13.5)	0.1
Age (years), < 65 vs ≥ 65	< 65 (15.0); ≥ 65 (11.5)	0.1
KPS, ≤ 70 vs >70	≤ 70 (11.5); >70 (20.3)	0.001	0.30 (0.1-0.68)	0.01
Primary tumor, breast cancer vs others	breast cancer (13.0); others (15.5)	0.2
Extracranial metastases, absent vs present	absent (22.5); present (11.2)	0.0001	0.10 (0.05-0.40)	0.001
Number of metastases, 1 vs > 1	1 met (15.5); >1 met (13.2)	0.3
Distant brain failure
Sex, male vs female	male (16.1); female (13.5)	0.9
Age (years), < 65 vs ≥ 65	< 65 (12.0); ≥ 65 (10.0)	0.2
KPS, ≤ 70 vs >70	≤ 70 (8.0); >70 (16.0)	0.03	0.36 (0.16-1.27)	0.1
Primary tumor, breast cancer vs others	breast cancer (10.0); others (14.0)	0.1
Extracranial metastases, absent vs present	absent (18.0); present (8.0)	0.002	0.18 (0.07-0.64)	0.01
Number of metastases, 1 vs > 1	1 met (16.0); > 1 met (10.0)	0.1

KPS, Karnofsky Performance Status.