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. 2014 May 28;5:223. doi: 10.3389/fpls.2014.00223

FIGURE 2.

FIGURE 2

Possible models for the regulation of gene transcription by CHD3 protein in plant and animal. (A) Hypothesized model for the regulation of gene transcription by plant CHD3 proteins. Plant CHD3 proteins act as monomer to repress or activate gene expression. The repression involves the association with H3K27me3 by PHD domain. However, it is not known whether the binding of CHD3 protein to H3K27me3 is necessary for the deposition of the mark ① or serves as a recognition mechanism for the protein to repress target gene expression ②. Plant CHD3 proteins are also required for the expression of many PcG target genes ③. (B) Model for the regulation of gene transcription by animal CHD3 proteins. Animal CHD3 proteins repress gene expression by composing NuRD complex with Histone deacetylase and other subunits. In Drosophila dMi-2 and dCHD3 also localize to actively transcribed regions to participate in the process of transcription.