Table 2.

Composite response criteria (combining radiographic and hearing response) for phase II studies of NF2-related VS

Radiographic response	Hearing response
	Major	Minor	Stable	Progressive
Major	Major response	Minor response	Minor response	Progressive disease
Minor	Minor response	Minor response	Stable disease	Progressive disease
Stable	Minor response	Stable disease	Stable disease	Progressive disease
Progressive	Progressive disease	Progressive disease	Progressive disease	Progressive disease

Major radiographic response is defined as ≥20% decrease in tumor volume compared to baseline; minor radiographic response is defined as 5–19% decrease in tumor volume compared to baseline. Major hearing response is defined as a statistically significant increase in word discrimination score compared to baseline; minor hearing response is defined as a decrease in PTA ≥10 dB in the setting of stable word recognition scores