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. 2014 Feb 19;289(15):10785–10796. doi: 10.1074/jbc.M113.536706

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Hypoformation of Meckel's cartilage in Lys-95 homozygotes. A, neural fiber organization of an E10.5 embryo was analyzed in whole mounts by immunochemical staining (2H3, anti-neurofilament antibody). There was no apparent difference between wild-type (Wild) and homozygous T95K (Homo) littermates. B, homozygous embryos show hypoformation of Meckel's cartilage. Typical pictures are shown for wild-type (Wild) and homozygous (Homo) E14.5 mouse embryos. Yellow arrowheads indicate hypoformation of the lower jaw. Bone preparations stained by Alcian blue and alizarin red are also shown. Red arrowheads (Meckel's cartilage) indicate hypoformation of the lower jaw.