FIGURE 8.

Inositol supplementation does not alleviate behavioral alterations in homozygote mice. A, schematic presentation of experiment schedules. Inositol was supplied for 6 weeks during the weaning period to rescue mutant mice. After this, rescued mice were raised on normal water for 6 weeks and then maintained with or without 4% myo-inositol. B, open field test. Note that inositol supplementation produced no apparent effect on open field activity in either genotype. C, wheel-running activity between DD cycles 11 and 13 under inositol supplementation. Wheel-running activity is presented as in Fig. 7, C and D.