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. 2014 Apr 17;7(6):613–623. doi: 10.1242/dmm.013904

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — GEMM primary tumors segregate by genotype. (A) Principal component analysis (PCA) on GEMM primary tumor samples and normal colon tissue. wt, normal colon from wild-type untreated mice. The following designations describe the alleles present in CRC GEMMs: A, Apc; AB, Apc, Braf; ABP, Apc, Braf, Tp53; AK, Apc, Kras; AKP, Apc, Kras, Tp53; AP, Apc, Tp53. (B) Unsupervised hierarchical clustering using the top 500 most differentially expressed genes from samples as described in A. WT, wild type.