Fig. 4.

Learning and memory in Shank3-deficient mice. (A) Fear conditioning. Training (left column) was altered in Shank3 heterozygous and knockout mice on the 129SVE (129) background, but no differences between the genotypes were found in either contextual (middle column) or cued recall (right column) phases. No differences between the genotypes were observed for C57 mice. All FVB mice were strongly impaired in all phases of the fear conditioning test. During cued recall, the percentage of mice that exhibited freezing behavior immediately after the first tone was lower in FVB Shank3-deficient animals than in wild-type. The x-axes indicate the time (minutes) for which the mice were recorded. (B) Y-maze spontaneous alternation. No differences were noted for the genotypes of 129SVE, C57 or FVB mice. The data represents means±s.e.m. ^oP<0.05, ^ooP<0.01, ^oooP<0.001 for wild-type (WT) versus heterozygous (Het) mice; *P<0.05, **P<0.01, ***P<0.001 for WT versus knockout (KO) mice; ^#P<0.05, ^##P<0.01, ^###P<0.001 for Het versus KO mice.