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. 2014 Apr 17;7(6):701–710. doi: 10.1242/dmm.014548

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Delayed treatment with HOE-140 protects mice from renal expression of pro-inflammatory and macrophage-related proteins that are induced by Adriamycin injection. Parameters were analyzed at 7 days after the injection of Adriamycin (ADM). HOE-140 prevented the upregulation of the expression of TNF-α renal protein (A) and renal protein expression of IL-1β (B) and IL-17 (C). The blockage of B2RBK also efficiently prevented the upregulation of the renal expression of macrophage-related chemokines, such as MCP-1 (D), macrophage inflammatory protein 1 α (MIP-1; also known as CCL3) (E) and RANTES (regulated on activation, normal T cell expressed and secreted; also known as CCL5) (F). *P<0.05 compared with that of control mice, ^#P<0.05 compared with that of mice treated with only ADM. Five animals were used per study group.