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. 2014 Apr 17;7(6):701–710. doi: 10.1242/dmm.014548

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Delayed HOE-140 treatment protects mice from renal expression of mRNAs that encode pro-inflammatory and pro-fibrotic molecules that are induced by Adriamycin injection. The parameters were analyzed at 7 days after the injection of 10 mg of Adriamycin (ADM) per kg of bodyweight into balb/c mice. HOE-140 prevented the upregulated expression of IL-1β mRNA (A). The blockage of B2RBK was also efficient in preventing the upregulation of B1RBK mRNA expression (B) and the pro-fibrotic molecules PAI-1 (C) and TGF-β (D). Expression of the mRNAs were normalized to that of hypoxanthine guanine phosphoribosyl transferase (HPRT). *P<0.05 compared with that of control mice, ^#P<0.05 compared with that of mice treated with only ADM. Five animals were used per study group.