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. 2014 May 7;6(5):2038–2051. doi: 10.3390/v6052038

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Cytomegalovirus (CMV) lung infection after steroid therapy. Three year old girl treated with systemic corticosteroid for autoimmune lymphoproliferative syndrome (ALPS). Chest-X-ray (CXR) shows diffuse haziness more prominent in the left base (A), which correspond to ground-glass images in CT scan (B). H&E staining revealed monocyte infiltration with cytomegalic changes in lung biopsy (black squares in panel C). Immunohistochemical detection of CMV (brown staining in D) showed typical CMV inclusion bodies (squares). Slides shown with 100× magnification.