Figure 1.

Circular map of GAS strain SSI-1. The outer circle shows the scale (bp). Rings 1 and 2 show the coding sequence by strands (ring 1, clockwise; ring 2, counterclockwise). The predicted ORFs are distinguished by different colors in the COG classification. Ring 3: The genes for bacteriophage (pink), transposase genes and insertion sequence (black), adhesion molecules (green), hyaluronidase genes (blue), and other putative virulence factors (red). Ring 4: The GC skew analysis. Ring 5: The G+C contents. Rings 6 and 7: The ribosomal RNA (red) genes and transfer RNA (blue) genes identified in the genome. Red arrows: The origin of DNA replication (ori; Suvorov and Ferretti 2000) and the putative region of replication terminus (ter).