Table 2.

Relationship between log urine total protein and binary outcomes

	Unadjusted	Adjusted*	Unadjusted	Adjusted*
	Total protein		Total protein-creatinine ratio
Low serum albumin	3.19 (2.74–3.71)	3.33 (2.50–3.95)	3.83 (3.25–4.50)	3.65 (3.06–4.37)
High serum cholesterol	1.48 (1.34–1.63)	1.52 (1.37–1.69)	1.48 (1.35–1.63)	1.45 (1.31–1.61)
Edema	1.66 (1.50–1.84)	1.47 (1.31–1.64)	1.64 (1.49–1.80)	1.51 (1.36–1.69)
All three signs and symptoms	3.15 (2.56–3.87)	3.20 (2.53–4.06)	3.44 (2.78–4.25)	3.13 (2.48–3.95)
Kidney disease progression	2.15 (1.90–2.43)	1.83 (1.60–2.10)	2.25 (1.99–2.54)	1.83 (1.60–2.09)
Kidney disease progression or death	2.04 (1.82–2.27)	1.84 (1.62–2.07)	2.22 (1.99–2.49)	1.96 (1.73–2.21)
	Albumin		Albumin-creatinine ratio
Low serum albumin	2.98 (2.58–3.44)	3.19 (2.69–3.78)	3.72 (3.16–4.38)	3.52 (2.95–4.19)
High serum cholesterol	1.45 (1.33–1.59)	1.50 (1.36–1.66)	1.47 (1.34–1.60)	1.44 (1.31–1.59)
Edema	1.59 (1.45–1.75)	1.42 (1.28–1.58)	1.59 (1.45–1.74)	1.47 (1.33–1.62)
All three signs and symptoms	3.01 (2.46–3.69)	3.16 (2.49–4.00)	3.49 (2.81–4.35)	3.17 (2.51–4.02)
Kidney disease progression	2.08 (1.85–2.34)	1.83 (1.60–2.08)	2.22 (1.97–2.50)	1.84 (1.61–2.09)
Kidney disease progression or death	1.91 (1.72–2.11)	1.75 (1.57–1.96)	2.10 (1.89–2.34)	1.87 (1.66–2.09)

Values are given as log base 2 odds ratio (95% confidence interval); OR signifies the risk for each doubling of urine protein measurement.

^*for age, sex, race, body mass index, insulin use, duration of diabetes, baseline angiotensin-converting enzyme inhibitor, systolic blood pressure, estimated glomerular filtration rate, hemoglobin level, and randomization assignment