Table 1.
Expression of Midkine Genes in Vertebrates
| Species | Embryonic expression | Adult expression | References |
|---|---|---|---|
| Human | liver, kidney; others nd. | not expressed, except in kidney and at very low levels in brain; highly expressed in certain tumors | Mishima et al. 1997,Kato et al. 2000 |
| Mouse | ubiquitous from E5.5 to E11 in brain, neural tube, upper and lower jaw, lung, scelerotome, limbs, intestine, stomach, pancreas, kidney from E11.5 to E13.5 | not expressed, except in kidney and at very low levels in brain | Kadomatsu et al. 1988 Kadomatsu et al. 1990 Muramatsu et al. 1993 Mitsiadis et al. 1995 Fan et al. 2000 |
| restricted to kidney at E15 | |||
| Xenopus | brain, branchial arches, neural tube | strong in brain, kidney, spleen, eye, spinal cord; weak in heart, lung, testis, stomach; not expressed in liver, intestine, muscle | Sekiguchi et al. 1995 |
| Chicken | throughout embryo but excluded from neural tube | nd. | Duprez et al. 1993 |
| Zebrafish mdka | paraxial mesoderm and somites; central neural tube; restricted areas in brain; | strong in brain; others nd. | this report |
| Zebrafish mdkb | restricted areas in the dorsal CNS | strong in brain; others nd. | Winkler and Moon 2001; this report |
(nd) Not determined.