Figure 1.

Sequence relationships between cyclins in mouse. (A) Phylogeny of mouse cyclins, based on multiple alignment of the conserved cyclin box domain. Values are shown for 1000 bootstraps. (B) Alignment of the core cyclin box domain of mouse cyclins. Shaded regions and underlying trace show regions of highest sequence similarity. CYCJ-Dm—Drosophila melanogaster cyclin J (AAC47017) is provided as a guide. UNG—Uracil-DNA glycosylase 2 has been recognized as a likely cyclin by a number of workers (Murray and Marks 2001). #: ANIA-6A has been assigned the symbol CCNL. ANIA-6B, which is clearly a paralog, has been assigned the symbol Pcee-pending. ^*-L-like and J-like cyclins identified in the present study.