Table 1.
Summary of Protein Domain Family Comparisons for Humans and Mice
| Protein domain | Human | Mouse | Only in RIKEN |
|---|---|---|---|
| Caspase | 11 | 10 | 0 |
| CARDa | 23 | 18 | 5 |
| DEDa | 11 | 11 | 0 |
| DD | 33 | 33 | 4 |
| BIR | 8 | 7b | 1 |
| Bcl-2 | 24 | 27 | 0 |
| TNF-ligands | 18 | 17 | 0 |
| TNF-Rs | 29 | 27 | 1 |
| TIR | 14 | 16 | 0 |
| TRAF/TEF | 14 | 18 | 1 |
| PAAD | 19 | 12 | 6 |
| NACHT | 20 | 16 | 6 |
| REL | 5 | 5 | 0 |
| IκB | 8 | 7 | 0 |
| BAG | 6 | 6 | 3 |
| CIDE | 5 | 5 | 0 |
| Other | 35 | 33 | 0 |
| Total | 283 | 265 | 27 |
| Total (adjusted) | (228) | (221) | (21) |
Caspases containing CARDs or DEDs are excluded from the results
, but other domain families are not corrected for redundancy. In addition to caspases, 23 genes create redundancy due to the presence of more than 1 of the domains listed above. The total number of apoptosis and inflammation-relevant genes after adjustment for redundancy is also provided. Cases in which the data were available only in the RIKEN database are noted. Other genes include para-Caspase (MALT), the IAP-binding proteins, Smac (Diablo), HtrA2 (Omi), XAF, the mitochondrial proteins cytochrome c, AIF, and EndoG, the transcription factors, p53, p65, and p73, the Bcl-2-binding proteins R-Ras, Raf1, Prp1, ANT1, ANT2, ANT3, VDAC1, VDAC2, VDAC3, Beclin, Bl-1, RTNx, Smn, Aven, Calcineurin-A, Calcineurin-B, Nip1, and Nip2 and the TRAF-binding proteins, I-TRAF (TANK), Trip, MIP-T3, TTRAP, KRC, TB2P, and TB2P-like
see Table 6 for details of BIR-domain (IAP) proteins