Figure 1. Oscillatory shear (OS) induces DNA hypermethylation in endothelial cells (ECs).
ECs were exposed to OS (0.5 ± 4 dynes/cm2) or PS (12±4 dynes/cm2) for 24 hr, and 5-meC level was determined by (A) immunofluorescent staining (images shown are representative from three independent experiments) and (B) Left: Immuno-slot blot using anti-5-meC. Right: The blot membrane was incubated with methylene blue to indicate equal loading of DNA.