Table 1.
Estimate of Gene Coverage in the RTPS Data Set
| Types | A | B | C | D |
|---|---|---|---|---|
| Receptors | ||||
| Acetylcholine receptors | ||||
| muscarinic | 5 | 4 | 0 | 1 |
| nicotinic | 16 | 16 | 0 | 2 |
| Dopamine receptors | 5 | 5 | 0 | 2 |
| GABA receptors | ||||
| ionotropic (A) | 19 | 18 | 0 | 2 |
| metabotropic (B) | 2 | 1 | 0 | 0 |
| Glutamate receptors | ||||
| ionotropic | 18 | 18 | 0 | 2 |
| metabotropic | 8 | 6 | 0 | 3 |
| Glycine receptors | 5 | 4 | 0 | 0 |
| Serotonin receptors | 15 | 14 | 0 | 1 |
| Ion Channels | ||||
| Calcium channels | 26 | 25 | 3 | 2 |
| Chloride channels | 13 | 12 | 2 | 1 |
| Potassium channels | 91 | 81 | 0 | 11 |
| Sodium channels | 21 | 18 | 0 | 1 |
| Gap Junctions | ||||
| Connexins | 19 | 18 | 1 | 1 |
Examples of receptors and channels have been analyzed for their representation in the RTPS dataset. Type A: Number of known members for each receptor or channel type established by cross comparison of mammalian species. B: Number of subtypes for which there is a representative clone in the RTPS dataset. C: Additional new genes previously unknown. D: Number of known genes for which FANTOM2 clones are the first sequence isolated in the mouse. The complete list of clones is shown in Supplementary Data #1 (receptors) and #2 (channels)
For ion channels, this analysis has been performed on the following gene families: voltage-dependent calcium channels (Cacna, Cacna2d, Cacnb, and Cacng); voltage-gated (Clcn) and calcium-activated (Clca) chloride channels; potassium channels Kcna, Kcnb, Kcnc, Kcnd, Kcnf, Kcng, Kcns, and Kfcnv: voltage-gated; Kcnq: m-current family; Kcnh: erg, eag, elk-related; Kcnj: inward rectifier; Kcnk: tandem-pore; Kcnma: large-conductance calcium-activated; Kcnn: small-conductance calcium-activated; Kcnab: beta subunits; Kcne: Isk-related, Kcnmb: large-conductance calcium-activated; Hcn: hyperpolarization-activated, cyclic nucleotide-gated (Coetzee et al. 1999); voltage-gated and epithelial sodium channels